For a pregnant patient with pyelonephritis, what is the most appropriate treatment option?

In the case of a pregnant patient with pyelonephritis, the most appropriate treatment option is IV ceftriaxone (Rocephin). This antibiotic is a broad-spectrum cephalosporin that is safe for use during pregnancy and effective in treating severe infections like pyelonephritis.

Ceftriaxone is typically chosen for its good penetration into the renal tissue and efficacy against commonly encountered pathogens in pyelonephritis, such as Escherichia coli and other gram-negative bacteria. Its safety profile during pregnancy further supports its use, as it does not pose the risks associated with other antibiotics that could potentially harm the developing fetus.

The other options are not suitable for various reasons. Oral ciprofloxacin (Cipro) belongs to the fluoroquinolone class, which is generally avoided in pregnancy due to concerns about potential adverse effects on cartilage development. Oral trimethoprim-sulfamethoxazole (Bactrim) is contraindicated during pregnancy, especially in the first trimester, because it can interfere with folate metabolism and has potential teratogenic effects. IV gentamicin (Garamycin), while effective for certain infections, is an aminoglycoside that poses risks of nephro