Use of systemic corticosteroids can cause which of the following adverse effects in the eye?

The use of systemic corticosteroids is known to elevate intraocular pressure, which can lead to the development of glaucoma. This condition is characterized by damage to the optic nerve, often caused by increased pressure within the eye. Chronic exposure to corticosteroids can decrease the outflow of aqueous humor, resulting in further pressure elevation. Patients undergoing treatment with systemic corticosteroids should be monitored for signs of glaucoma, especially those with pre-existing risk factors or a history of ocular conditions.

The other options, while they may be relevant in other contexts, do not correlate directly with the well-established side effects of systemic corticosteroids. Cortical blindness is typically associated with central nervous system issues rather than corticosteroid use, optic atrophy usually stems from direct optic nerve damage rather than steroid exposure, and papilledema generally reflects increased intracranial pressure rather than intraocular pressure specifically induced by corticosteroids. Thus, glaucoma stands out as the key adverse effect related to the use of systemic corticosteroids in relation to eye health.