What is the treatment of choice for actinic keratosis?

Cryotherapy is considered the treatment of choice for actinic keratosis because it effectively destroys the abnormal keratinocytes, which are the cells that have undergone precancerous changes due to excessive sun exposure. In this procedure, liquid nitrogen is applied to the lesion, resulting in cell freeze and subsequent destruction of the affected skin. This method is favored for its reliability, minimal scarring, and ease of use in an outpatient setting.

Other treatments, while they may be effective in certain contexts, do not hold the same level of standing for actinic keratosis. Mohs surgery is more invasive and is typically reserved for skin cancers rather than precancerous lesions. Acid peels can be used for superficial lesions, but they are not as commonly utilized for actinic keratosis compared to cryotherapy. Radiation therapy is generally not appropriate for actinic keratosis as it is reserved for more advanced skin cancers.