Which medication is most appropriate for mild, intermittent symptoms of gastroesophageal reflux disease?

The most appropriate medication for mild, intermittent symptoms of gastroesophageal reflux disease (GERD) is ranitidine (Zantac). Ranitidine is an H2 receptor antagonist that works by decreasing the amount of acid produced by the stomach. This action can help alleviate symptoms of GERD, such as heartburn and acid regurgitation, especially when they occur infrequently.

In the context of managing mild and intermittent symptoms, using an H2 blocker like ranitidine is often a first-line approach because it provides relief from discomfort without the necessity for more potent or continuous treatments. It is well-suited for patients who may not require daily medication or those who experience symptoms on an as-needed basis.

Other medications listed, such as sucralfate, metoclopramide, and misoprostol, are generally not the first line for this scenario. Sucralfate acts primarily by forming a protective barrier on the gastric lining, which does not address the acidity that causes symptoms. Metoclopramide, while effective for gastroparesis and nausea, may have limited efficacy for straightforward GERD symptoms and carries a risk of extrapyramidal side effects. Misoprostol is primarily used to prevent NSAID-induced ulcers