Which risk factor significantly increases the chance of developing testicular cancer?

The history of cryptorchidism, or undescended testicles, is a well-established risk factor for testicular cancer. During fetal development, if one or both testes do not descend into the scrotum, this condition can lead to a higher risk of developing cancer in that testicle later in life. The exact reason for this increased risk is thought to relate to abnormal testicular development and exposure to higher temperatures within the body rather than the cooler environment of the scrotum.

Individuals with a history of cryptorchidism are advised to monitor testicular health closely and may be recommended to undergo routine examinations or self-examinations to check for any unusual changes. This highlights the importance of familial and medical history in assessing individual risk for testicular cancer. Understanding these risk factors helps inform preventive health measures and screening recommendations.