Which treatment is ideal for managing duodenal ulcers associated with H. pylori infection?

The ideal treatment for managing duodenal ulcers associated with H. pylori infection involves combined therapy with antibiotics and proton pump inhibitors. This combination targets the underlying cause of the ulcers, which is the H. pylori infection, while also reducing gastric acid secretion to promote healing.

Proton pump inhibitors (PPIs) are effective in decreasing gastric acidity, creating a less hostile environment for the healing of the ulcer. They also enhance the efficacy of the antibiotics by stabilizing the pH, which can improve the absorption of certain antibiotics. The antibiotics work to eradicate H. pylori, thus addressing the etiological factor contributing to the ulcer formation.

This dual approach is supported by clinical guidelines, as it not only treats the ulcer but significantly reduces the risk of recurrence by eliminating the infection.

In contrast, using proton pump inhibitor therapy alone does not address the bacterial infection, leaving the underlying cause untreated. Sucralfate as monotherapy only provides a protective barrier over the ulcer but does not eradicate H. pylori or decrease acid production, making it insufficient for treating ulcers associated with this infection. Surgical intervention is rarely indicated for duodenal ulcers unless there are complications or significant refractory cases, and it is not the first line of treatment. Thus, the